Best Supplements for Men: For More Muscle, Higher Testosterone, Longer Life, and Better Looks by P. D. Mangan
Author:P. D. Mangan
Language: eng
Format: mobi
Publisher: Phalanx Press
Published: 2017-05-11T18:30:00+00:00
Psychiatric illness
Chronic fatigue
Influenza
Heavy metal chelation
Aging
NAC replenishes glutathione, including in the brain, and this is likely its mechanism of action in various psychiatric illnesses.
Bipolar depression: An open-label trial of NAC in patients with bipolar depression yielded “a robust decrement in depression scores”. The patients took 1 gram NAC, twice a day, and this was as “a maintenance treatment for bipolar disorder.”[204]
Addiction: NAC has been studied for its effects in cocaine, marijuana, and nicotine addiction, with varying success, and studies are ongoing.[205]
NAC in chronic fatigue: NAC may be useful in treating chronic fatigue. In chronic fatigue, oxidative damage to DNA is higher than in controls, which indicates the presence of oxidative stress.[206] It’s been speculated that competition between the immune system and muscle for glutathione precursors such as cysteine favors the immune system.[207] When that happens, muscles become depleted of glutathione and cannot function properly, leading to fatigue and myalgia. A number of studies have found depleted levels of glutathione in chronic fatigue syndrome, and n-acetylcysteine results in improvement of symptoms.[208]
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